Carbon Nanofibers Have IgE Adjuvant Capacity but Are Less Potent Than Nanotubes in Promoting Allergic Airway Responses

Carbon Nanofibers Have IgE Adjuvant Capacity but Are Less Potent Than Nanotubes in Promoting Allergic Airway Responses

There is a growing concern for the possible health impact of nanoparticles. The main objective of this study was to investigate the allergy-promoting capacity of four different carbon nanofiber (CNF) samples in an injection and an airway mouse model of allergy. Secondly, the potency of the CNF was compared to the previously reported allergy-promoting capacity of carbon nanotubes (CNT) in the ai...

Ultrafine carbon black particles cause early airway inflammation and have adjuvant activity in a mouse allergic airway disease model.

To gain more insight into the mechanisms of particulate matter (PM)-induced adjuvant activity, we studied the kinetics of airway toxicity/inflammation and allergic sensitization to ovalbumin (OVA) in response to ultrafine carbon black particles (CBP). Mice were exposed intranasally to OVA alone or in combination with different concentrations of CBP. Airway toxicity and inflammation were assesse...

Inflammation in a Murine Model Inducers Than Antigen Alone of Airway Immune Complexes Are More Potent Role for IgE in Airway Secretions: IgE

Catalytic Synthesis of Carbon Nanotubes and Nanofibers

Carbon nanotubes and nanofibers are graphitic filaments/whiskers with diameters ranging from 0.4 to 500 nm and lengths in the range of several micrometers to millimeters. Carbon nanofibers and nanotubes are grown by the diffusion of carbon (via catalytic decomposition of carbon containing gases or vaporized carbon from arc discharge or laser ablation) through a metal catalyst and its subsequent...

Hunter-gatherers have less famine than agriculturalists.

The idea that hunter-gatherer societies experience more frequent famine than societies with other modes of subsistence is pervasive in the literature on human evolution. This idea underpins, for example, the 'thrifty genotype hypothesis'. This hypothesis proposes that our hunter-gatherer ancestors were adapted to frequent famines, and that these once adaptive 'thrifty genotypes' are now respons...